The Wagner laboratory is looking for an undergraduate student with interests in biochemical research. The primary focus of this project relates to studying the Integrator complex and its roles in transcriptional regulation. The Integrator Complex has been shown to function in the pause/release of RNAPII at many protein-coding genes as well as transcription termination of subclasses of non-coding RNAs. The Wagner laboratory is interested in determining the mechanism of Integrator action at these various gene types. To that end, we have developed model systems in both human and Drosophila cells in address its various unknowns. This project will enable a student to receive training in many aspects of biochemistry and molecular biology including chromatin biology techniques to study factors associated with Integrator.